March Madness 2025: Duke, Florida enter second round as outright title favorites

March Madness action rolls into the second round on Saturday.

After the first round was dominated by the top seeds in somewhat historic fashion, the second round features all the usual suspects. And that means the teams that entered the postseason with the best odds to win the tournament are all left standing. Below, you can find the latest March Madness odds, including odds to win each region and advance to the Final Four.

National Championship odds

odds via ESPN Bet

Texas A&M (+8000), Arkansas (+12500), and Ole Miss (+12500) are all considered long shots to win the title.

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Odds to win the East Region

Duke (-145) is the outright favorite to win the East Region and advance to the Final Four. Alabama has the next-best odds at +425. Arizona, the 4-seed in the region, has shorter odds (+900) than 3-seed Wisconsin (+1200). Should the Wildcats beat Oregon on Sunday, they’ll potentially meet Duke in the Sweet 16. Arizona lost 69-55 to Duke during the regular season.

Oregon (+2800) and Baylor (+2800) have the longest odds to win this region.

Odds to win the South Region

Auburn (-110) is the outright favorite to win the South. The 3-seed in this portion of the bracket, Iowa State, is viewed as the bigger threat to Auburn. The Cyclones are +400 to win the region while 2-seed Michigan State is priced at +425. Iowa State is notably playing without star guard Keshon Gilbert, the team’s second-leading scorer at 13.4 points per game.

Texas A&M is +800 to win the region. New Mexico (+4000) is the deep sleeper as the lowest-seeded team in this part of the bracket.

Odds to win the West Region

Florida (-115) is the favorite to win the West, which should come as no surprise after the Gators won the SEC Tournament and followed that up with a resounding victory over Norfolk State in the NCAA Tournament’s opening round. St. John’s (+425) and Texas Tech (+425) are both viewed as equally dangerous threats to knock off the Gators and advance to the Final Four. Maryland is +550. Arkansas is +2200 while Drake is +3300.

UConn, the 2-time defending national champ, is +1500 to win the region. The Huskies battle the Gators on Sunday. Colorado State (+5000) has the longest odds to make the Final Four of any team left in the West.

Odds to win the Midwest Region

Houston is the only 1-seed at ESPN Bet with plus odds to win its region. The Cougars are +135, implying a 42.6% likelihood they advance to the Final Four. Tennessee is +275 to win the region while Gonzaga (+425) holds the next-shortest odds.

The Zags will battle the Cougs in the second round on Saturday in what looks like the most dangerous second-round matchup for any of the 1-seeds. Gonzaga won its first-round game with Georgia by 21 points. The Zags are also ranked eighth nationally in KenPom. They are 4 spots above 2-seed St. John’s; they are rated higher than every 3-seed in the field and every 4-seed in the field.

Duke’s second-round matchup is against KenPom’s No. 29 team. Auburn’s second-round matchup is against KenPom’s No. 35 team. Florida’s is against KenPom’s No. 32 team.

Elsewhere, Purdue is +900 to win the region. Kentucky (+1000) and UCLA (+1500) are the dark horses while McNeese (+5000) is the real long shot.

Derek Peterson

Derek Peterson does a bit of everything, not unlike Taysom Hill. He has covered Oklahoma, Nebraska, the Pac-12, and now delivers CFB-wide content.